Defence, Midfield and Attack
Since the arrival of Ralf Rangnick as interim manager, Dalot has been able to establish himself in the first-team and appears to be comfortably ahead of Aaron Wan-Bissaka in the pecking order right now.
Varane has not been at the top of his game since arriving at Manchester United but the Red Devils might have to rely on the experience of the four-time Champions League winner in this competition.
Maguire has had his fair share of problems throughout the season but has shown promising signs of improvement.
Shaw appears to have established himself as the starting left-back at Manchester United once again with several impressive displays.
Fred proved to be the difference maker against Leeds United at the weekend and might get the nod from the start against Atletico Madrid.
Pogba has been absolutely brilliant ever since returning to action from his recent injury and appears to be thriving in this system.
Many might question whether Elanga is ready to start in a game of this magnitude but his recent performances suggest that Manchester United are more likely to win with him in the team than without.
Fernandes has rediscovered some of his form in recent weeks and can be a difference maker for Manchester United once again.
Speaking of rediscovering form, Sancho has been superb lately and is slowly but surely starting to look like the player that Manchester United signed from Borussia Dortmund in the summer.
Ronaldo has proven to be Atletico Madrid’s Achilles’ heel on numerous occasions in the past. Fans will be hoping that he can repeat that this time around as well. But at 37 years of age, does the Portuguese legend have another classic Champions League performance left in the tank?